Part 1 Concept of Asthma COPD overlap.- 1 Concept of Asthma COPD overlap - Japanese guideline and global trends. How was the concept of Asthma COPD overlap developed and moving forward? .- 2 Concept of treatable traits and ACO (2): Can treatable traits approach be applied into practice? .- Part 2 Epidemiology and Prognosis.- 3 Epidemiology of ACO from global data: Does the prevalence of ACO vary among global analyses? .- 4 Epidemiology of ACO defined by the JRS guidelines. What is the prevalence of ACO in Japan? .

- 5 Prognosis and characteristics of ACO: What are the specific characteristics of ACO?- 6 Prognosis of COPD with asthma-like features and ACO: Is the prognosis of COPD and ACO different? .- 7 Causes of death in patients with asthma-chronic obstructive pulmonary disease overlap: Is there any difference compared to asthma?.- Part 3 Pathophysiology of ACO.- 8 Inflammatory phenotypes and potential bio-markers of ACO. What is the specific feature of ACO? .- 9 Role of Nitrosative stress: What is the potential clinical implication?.- 10 Radiographic features of ACO. How the feature is applied into practice?.

- 11 Pulmonary Function of ACO: What is the role of the forced oscillation technique?.- 12 Underlying mechanism suggested by the ACO model. What is the lesson learned from the model?.- Part 4 Diagnosis of ACO.- 13 Comparison of diagnostic criteria of ACO: What is the point of difference?.- 14 Role of FeNO - How can FeNO be positioned in practice?.- 15 Role of IgE and Eosinophils: The use of type 2 biomarkers in practice.- 16 Rhinosinusitis in ACO: What is the implication of nasal comorbidity?.

- Part 5 Treatment.- 17 Current evidence of treatment for asthma-COPD overlap (ACO): Is there emerging evidence of optimal therapy? .- 18 Potential treatment options for ACO, including biologics: Are there any roles of biologics?.