SECTION I Regulation of Gene Expression, Hormone Synthesis, and Hormone Secretion Chapter 1 Pancreatic Development in the Context of Diabetes Chapter 2 Glucagon: From Gene Regulation to Secretion Chapter 3 Insulin Production, Processing, and Secretion Chapter 4 Incretins: From Gene Expression to Secretion and Action of GLP-1 and GIP SECTION II Hormone Action Chapter 5 Glucagon Synthesis, Secretion, and Mechanisms of Action Chapter 6 Insulin Structure and Function Chapter 7 Common Mechanisms of Insulin Signaling, Action, and Resistance Chapter 8 Insulin Receptor Structure and Function Chapter 9 Insulin Action in Liver, Skeletal, Muscle, and Adipose Tissue: A Focus on Humans Chapter 10 Insulin Action in the Brain Chapter 11 Insulin Action in the Cardiovascular System Chapter 12 Metabolic Regulation by Adipokines, Hepatokines, and Myokines SECTION III Genetics of Diabetes Chapter 13 Genetics of Monogenic Forms of Diabetes Chapter 14 Genetics of Type 1 Diabetes Chapter 15 Genetics of Type 2 Diabetes SECTION IV Type 1 Diabetes Chapter 16 Spotlight on the Pathology of Type 1 Diabetes SECTION V Type 2 Diabetes Chapter 17 Heterogeneity of Type 2 Diabetes Mellitus Chapter 18 Cystic Fibrosis-Related Diabetes SECTION VI Complications of Diabetes Chapter 19 Intranuclear Beta Cell Nrf2 Expression in Type 2 Diabetes and the Potential Use of Glutathione Peroxidase Mimetics for Early Treatment Chapter 20 Diabetic Retinal Disease Chapter 21 Understanding Diabetic Neuropathy: From Pathophysiology to Therapeutic Targets SECTION VII Pharmacology and Drugs Chapter 22 SGLT2 Inhibitors and Slowing Kidney Disease Progression From Diabetes Chapter 23 Advanced Technology in Diabetes: Sensors and Pumps Chapter 24 Pancreas and Islet Cell Transplantation for Diabetes Chapter 25 Stem Cell-Derived Islet Therapy for Type 1 Diabetes.