In this issue of Clinics in Liver Disease , guest editors Drs. Gidgeon Hirschfield and Aliya Gulamhusein bring their considerable expertise to the topic of Advances in Cholestatic Liver Disease . Top experts discuss the pathophysiological basis to chronic cholestasis alongside a review of the patient journey from diagnostic approach, differential causes, symptom burden, complications, and end stage liver disease. Contains 13 relevant, practice-oriented topics including the scientific basis of cholestatic liver disease and its symptom complex; overlap syndromes with PBC and PSC; genetic cholestatic syndromes; general hepatology concerns for the patient with cholestatic liver disease; PSC-associated cholangiocarcinoma; and more Provides in-depth clinical reviews on advances in cholestatic liver disease , offering actionable insights for clinical practice Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.