In this issue of Hematology/Oncology Clinics, guest editor Dr. Sara Zarnegar-Lumley brings her considerable expertise to the topic of Updates in Pediatric Oncology. Top experts provide up-to-date analyses of key topics within pediatric oncology, such as oncofertility in pediatric and adolescent patients; subsequent malignant neoplasms in childhood cancer survivors: identifying risks and screening recommendations; neurocognitive late effects among childhood cancer survivors: a holistic review of clinical risk factors; and more. Contains 8 relevant, practice-oriented topics, including big data in pediatric oncology: hope, hype, reality; advances in pediatric Hodgkin lymphoma with an eye on disparities and vulnerable populations; advances in pediatric radiation oncology: proton therapy; updates in childhood leukemia; and more. Provides in-depth clinical reviews on updates in pediatric oncology, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.