Part I - Epidemiology and diagnosis 1. Introduction 2. The patient 3. Practicing law with lupus: the story of a patient 4. Epidemiology 5. Measuring disease activity 6. Disease development and outcome 7. Socioeconomic aspects of SLE 8.
Biomarkers in systemic lupus erythematosus 9. Biomarkers in lupus nephritis Part II - Pathogenesis 10. Overview of the pathogenesis of systemic lupus erythematosus 11. System lupus erythematosus and the environment 12. Genes and genetics in human SLE 13. Monogenic lupus 14. Hormones 15. Clinical aspects of the complement system in systemic lupus erythematosus 16.
T cells 17. B cells in SLE 18. Neutrophils in systemic lupus erythematosus 19. The role of dendritic cells in systemic lupus erythematosus 20. Platelets in lupus 21. Cytokines 22. RNA/DNA sensing in SLE--Toll-like receptors and beyond 23. The role of interferons in systemic lupus erythematosus 24.
Fcγ receptors in autoimmunity and end organ damage 25. Apoptosis, autophagy, and necrosis 26. Infections in early systemic lupus erythematosus pathogenesis 27. Microbiota influences on systemic lupus erythematosus and Sjögren's syndrome 28. Origin of autoantibodies 29. Anti-DNA antibodies 30. Antihistone and antispliceosome antibodies 31. Immune complexes in systemic lupus erythematosus 32.
MicroRNA in systemic lupus erythematosus 33. Metabolic control of lupus pathogenesis 34. Epigenetics 35. What do mouse models and genetics teach us about human SLE? Part III - Mechanisms of tissue damage 36. Mechanisms of renal damage in systemic lupus erythematosus 37. Mechanisms of vascular damage in systemic lupus erythematosus 38. The mechanism of skin damage 39. Pathogenesis of tissue injury in the brain in patients with systemic lupus erythematosus Part IV - Clinical aspects of the disease 40.
Constitutional symptoms and fatigue in systemic lupus erythematosus 41. The musculoskeletal system in SLE 42. Cutaneous lupus erythematosus 43. The clinical evaluation of kidney disease in systemic lupus erythematosus 44. The pathology of lupus nephritis 45. Cardiovascular disease in systemic lupus erythematosus: an update 46. The lung in systemic lupus erythematosus 47. Gastrointestinal, hepatic, and pancreatic disorders in systemic lupus erythematosus 48.
Systemic lupus erythematosus and infections 49. Malignancies in systemic lupus erythematosus 50. The nervous system in systemic lupus erythematosus 51. Psychiatric lupus 52. Overlap syndromes 53. Systemic lupus erythematosus and the eye 54. Fertility and pregnancy in systemic lupus erythematosus 55. Neonatal lupus: Clinical spectrum, biomarkers, pathogenesis, and approach to treatment 56.
Incomplete lupus syndromes 57. Lupus in children and adolescents 58. Drug-induced lupus 59. Vasculitis in lupus 60. Accrual of organ damage in lupus Part V - Antiphospholipid Syndrome 61. Pathogenesis of antiphospholipid syndrome 62. Antibodies and diagnostic tests in antiphospholipid syndrome 63. Clinical manifestations Part VI - Treatment 64.
Nonsteroidal anti-inflammatory drugs in systemic lupus erythematosus 65. Value of antimalarial drugs in the treatment of lupus, 66. Systemic glucocorticoids 67. Cytotoxic drug treatment 68. Treatment of antiphospholipid syndrome 69. New treatments of systemic lupus erythematosus 70. Cell therapies in lupus.