Preface xxvii 1 Immunotherapy: Unveiling Myths, Shaping Reality, Charting Ideas, and Mapping the Future 1 K. Trideva Sastri, Dinesh Murugan M., Meghana G.S. and Balamuralidhara V. 1.1 Introduction 2 1.2 Understanding Immunotherapy in Alzheimer''s Disease 5 1.
3 Unveiling the Myths Surrounding Immunotherapy 8 1.4 Shaping the Reality of Immunotherapy 11 1.5 Charting Ideas: Emerging Trends in Immunotherapy 13 1.6 Mapping the Future of Alzheimer''s Care with Immunotherapy 24 1.7 Overcoming Barriers in Translating Research to Clinical Practice in Immunotherapy Treatment of Alzheimer''s Disease 26 1.8 Conclusion 28 2 Amyloid-β Immunotherapy: Bridging Gaps in Alzheimer''s Strategies 49 P. K. Sahu, S.
K. Prusty, M. Khandai and D. S. Panda 2.1 Introduction 50 2.2 AD Pathogenesis 51 2.3 Advances in AD Treatment 52 2.
4 Advantages and Challenges 67 2.5 Bridging Gaps in Alzheimer''s Strategies 68 2.6 Conclusion 70 2.7 Future Directions 70 3 Advancing Strain-Specific Immunotherapy for Alzheimer''s Disease and Tauopathies: Opportunities and Challenges 79 Sindhu Priya E. S., Sandhya Vasanth, Tahreen Taj, Mohammed Ameen M. P., Seleshya S.
Danam and M. Vijay Kumar 3.1 Introduction 80 3.2 Background on Alzheimer''s Disease and Tauopathies 82 3.3 Current Immunotherapy Approaches for Alzheimer''s Disease 86 3.4 Rationale for Strain-Specific Immunotherapy 90 3.5 Opportunities in Strain-Specific Immunotherapy 92 3.6 Innovative Techniques in Strain-Specific Targeting 93 3.
7 Preclinical and Clinical Studies: Current Status and Findings 94 3.8 Future Directions and Emerging Trends 104 4 Synergistic Approaches: Natural Products, Small Molecules, and Immunotherapy in Brain Disorder Management 119 Prashant Tiwari, Sunil Kumar Kadiri, Neha Minocha and Astha Singh 4.1 Introduction 120 4.2 Natural Products in Brain Disorder Management 123 4.3 Small Molecules in Brain Disorder Management 132 4.4 Immunotherapy in Brain Disorder Management 137 4.5 Synergistic Approaches 139 4.6 Emerging Trends and Innovations in Synergistic Approaches for Brain Disorder Management 145 4.
7 Challenges 146 4.8 Future Directions 148 4.9 Conclusion 151 5 Deciphering the Role of Cytokines in Neuroinflammation: Implications for Therapeutic Targeting 161 Kushagra Nagori, Rashnita Sharma, Anshita Shukla, Reena Deshmukh, Rashi Banchhor, Kartik T. Nakhate, Madhulika Pradhan, Krishna Yadav, Mukesh Kumar Sharma and Aakash Gupta 5.1 Introduction 163 5.2 CY Families and Their Role in Neuroinflammation 164 5.3 Cellular Sources of CY in the CNS 166 5.4 Mechanisms of CY Signaling in the CNS 170 5.
5 Anti-Inflammatory CY: Regulation and Therapeutic Potential 172 5.6 CY Dysregulation in Specific Neurodegenerative Disorders 173 5.7 Therapeutic Targeting of CY 175 5.8 Conclusion 176 6 Therapeutic Potential of TREM-1 Modulation in Alzheimer''s Disease 185 Pragati A. Dongare, Deepak Khobragade, Surendra Agrawal and Mrunali Potbhare 6.1 Introduction 186 6.2 TREM-1: Structure and Function 190 6.3 TREM-1 in Neuroinflammation and AD 192 6.
4 Potential Mechanisms of TREM-1 Modulation in AD Therapy 194 6.5 Therapeutic Strategies Targeting TREM-1 in AD 196 6.6 Preclinical and Clinical Studies on TREM-1 in AD 198 6.7 Challenges and Future Perspectives 199 6.8 Conclusions 201 7 Personalized Immunotherapy in Brain Disorders: Precision Medicine Insights 209 Bhaskar Pal, Kushal Roychoudhuri and Moitreyee Chattopadhyay 7.1 Introduction 210 7.2 Overview of Precision Medicine 211 7.3 Immunotherapy Technologies 213 7.
4 Personalized Immunotherapy Targeting Cancer-Specific Neoantigen 221 7.5 Role of Emerging Biomarkers for Personalized Immunotherapies 222 7.6 Challenges and Limitations of Recent Biomarkers to Identify Response to Immune Therapies 223 7.7 Use for Brain Diseases 224 7.8 Technology Innovation 228 7.9 Clinical Trials 229 7.10 Challenges and Limitations 231 7.11 Future Direction 232 7.
12 Conclusion 233 8 Hematological Considerations in Immunotherapy for Alzheimer''s Disease 247 Ritu Raj Kumar, Rohit Pandey, Sonakshi Antal, Shobha Rani and Md. Sarfraj Alam 8.1 Introduction 248 8.2 Patient-Centered Perspectives in Immunotherapy for Alzheimer''s Disease 256 8.3 Future Directions in Immunotherapy for Alzheimer''s Disease 261 8.4 Conclusion 263 9 Innovative Strategies for Genetic Predispositions in Alzheimer''s: Immunotherapy and Gene Therapy Integration 273 Shukla Rajendra Kumar, Shah Nishi, Bohra Bhavna, Saxena Bhagawati and Gupta Richa 9.1 Introduction to Alzheimer''s Disease 274 9.2 Global Statics of Alzheimer''s Disease 275 9.
3 Pathophysiology of Alzheimer''s: Amyloid Plaques, Neurofibrillary Tangles, and Neuroinflammation 275 9.4 Current Diagnostic Challenges and the Need for Innovative Approaches 280 9.5 Gene Therapy: Harnessing Genetic Engineering for Alzheimer''s 280 9.6 Immunotherapy: A Promising Frontier in Alzheimer''s Treatment 284 9.7 Integrating Immunotherapy and Gene Therapy: A Synergistic Approach 290 9.8 Preclinical and Clinical Trials: Progress and Challenges 292 9.9 Conclusion: The Road Ahead for Alzheimer''s Treatment 294 10 Facilitating Synaptic Repair: Immune System Involvement 305 Gaurav Mude, Mohammad Tauqeer Sheikh, Shantilal Singune, Sanjay Nagdev and Junaid Tantray 10.1 Introduction to Synaptic Repair 306 10.
2 The Immune System and the Central Nervous System (CNS) 307 10.3 Microglia: Sentinels and Sculptors of Synaptic Networks 310 10.4 Astrocytes and Synaptic Support 313 10.5 Peripheral Immune Cells in Synaptic Repair 315 10.6 Molecular Signals Mediating Immune-Synapse Communication 317 10.7 Fractalkine and Other Key Signaling Pathways 319 10.8 Neuroinflammation: Double-Edged Sword 320 10.9 Synaptic Dysfunction in Neurodegenerative Diseases 322 10.
10 Therapeutic Strategies Targeting Immune Pathways 324 10.11 Cell-Based Approaches to Promote Synaptic Healing 326 10.12 Biomaterials and Immunomodulation 328 10.13 Challenges and Risks in Manipulating Immune Responses 331 10.14 Future Directions in Synaptic Repair Research 333 11 Exploring Ion Channel-Linked Strategies in Immunotherapy for Neurological Disorders 341 Hariprasad M.G., Sourav Guha and Moqbel Ali Moqbel Redhwan 11.1 Introduction 342 11.
2 Neurodegenerative Diseases and Their Pathophysiology 344 11.3 Ion Channels and Their Types: Overview 349 11.4 Types of Ion Channels in Neurons 355 11.5 Ion Channels Present in Different Parts of Neurons 357 11.6 Role of Ion Channels in Neuronal Excitability, Signaling, and Plasticity 359 11.7 Immune Signaling in Neurodegeneration 361 11.8 Immunotherapy 362 11.9 Immunotherapy in Neurodegenerative Diseases 363 11.
10 Immunotherapy Approaches in Neurodegenerative Diseases 364 11.11 Inhibiting Pathogenic Immune Signaling 366 11.12 Intersection of Immunotherapy and Ion Channels 367 11.13 Immunotherapeutic Agents Targeting Ion Channels in Neurodegenerative Disorders 368 11.14 Challenges and Limitations of Immunotherapy in Neurodegenerative Disorders 370 12 Strategies for Inflammation Control: Modulating Microglial Responses 385 Faizan Khalid, Ashwini Deshpande and D. S. N. B.
K. Prasanth 12.1 Introduction 386 12.2 Microglial Activation and Its Role in Inflammation 389 12.3 Pathophysiological Implications of Microglial Dysregulation 391 12.4 Molecular Targets for Modulating Microglial Responses 394 12.5 Pharmacological Strategies 396 12.6 Nonpharmacological Interventions 406 12.
7 Emerging Approaches and Future Directions 416 12.8 Challenges and Limitations 419 12.9 Conclusions 422 13 Revolutionizing Neuroprotection: Innovative Lysosomal Targeting Strategies 433 Ahana Hazra, Rideb Chakraborty, Naureen Afrose, Pratibha Bhowmick and Mithun Bhowmick 13.1 Introduction 434 13.2 Tackling of Neurodegeneration 435 13.3 CNS-Targeting Treatments for Lysosomal Keeping Diseases: Current Advancements and Challenges 440 14 Ensuring Safety: Immunotherapy and Adverse Effect Management in Cerebrospinal Fluid 461 Pankaj Malhotra, Neha Minocha, Prashant Tiwari, Sunil Kumar Kadiri and Sampriti Paul 14.1 Introduction 462 14.2 Role of Immunotherapy in Neurological Disorder 468 14.
3 Mechanisms of Adverse Effects in Immunotherapy 474 14.4 Diagnostic Strategies for Adverse Effects 476 14.5 Management of Immunotherapy in CSF Disorders 479 14.6 Future Development 480 14.7 Conclusion 484 15 Phytosomes and Blood Barrier Integrity: Implications for Immunotherapy Sustainability 493 Akanksha and Sajeev Kumar B. 15.1 Introduction 494 15.2 Considerations for Drug Delivery to the Brain 503 16 Therapeutic Insights: Acetylcholinesterase Inhibitors and Immunotherapy for Alzheimer''s Disease 521 Rashmi Madhariya, Vikas Kumar, Prince Nikhil Rathore and Alpana Ram 16.
1 Introduction 522 16.2 Acetylcholinesterase Inhibitors (AChEIs) 526 16.3 Treatment for ADs Using Immunotherapy 535 16.4 Comparative Insights: AChEIs vs. Immunotherapy 547