SECTION 1: GYNECOLOGIC CYTOPATHOLOGY OVERVIEW Pap Test and Cervical Cancer Screening: History and Reporting Terminology Cytopreparation, Instrumentation, and Automated Screening in Gynecologic Cytology Specimen Adequacy in Cervicovaginal Cytology BENIGN AND INFECTIOUS CONDITIONS Normal Pap Test Infectious and Other Organisms in Pap Tests Nonneoplastic Findings, Mimics, and Artifacts SQUAMOUS CELL ABNORMALITIES AND MIMICS Low-Grade Squamous Intraepithelial Lesion and Mimics High-Grade Squamous Intraepithelial Lesion and Mimics Atypical Squamous Cells of Undetermined Significance Atypical Squamous Cells, Cannot Rule Out High-Grade Squamous Intraepithelial Lesion Squamous Cell Carcinoma of Cervix GLANDULAR CELL ABNORMALITIES Endocervical Adenocarcinoma In Situ, Variants and Mimics Endocervical HPV-Dependent Invasive Adenocarcinoma Endocervical HPV-Independent Gastric Type Adenocarcinoma Endometrial Cancers in Pap Tests Atypical Glandular Cells: Endocervicals, Endometrials, and Glandulars, NOS Endometrial Cells in Pap Test and Glandular Cells Status Post Hysterectomy EXTRAUTERINE CARCINOMAS AND OTHER MALIGNANCIES OF FEMALE GENITAL TRACT Extrauterine Cancers in Pap Tests Neuroendocrine Carcinoma of Cervix Other Uncommon Malignancies in Pap Tests MOLECULAR TESTING IN GYNECOLOGIC CYTOLOGY HPV and Other Molecular Testing in Gynecologic Cytology DIRECTLY SAMPLED ENDOMETRIAL CYTOLOGY Directly Sampled Endometrial Cytology ANAL CYTOLOGY Anal Cytology SECTION 2: EXFOLIATIVE CYTOPATHOLOGY GASTROINTESTINAL TRACT Specimen Types in Respiratory Cytology and Adequacy Criteria Parasitic Infections Viral Infections Esophagitis and Barrett Esophagus Esophageal Adenocarcinoma Esophageal Squamous Cell Carcinoma Gastritis and Intestinal Metaplasia Gastric Adenocarcinoma Gastric Lymphoma Glomus Tumor Ampulla/Bile Duct/Pancreatic Duct Reactive Changes Ampulla/Bile Duct/Pancreatic Duct Adenocarcinoma Colorectal Adenoma/Carcinoma Neuroendocrine Tumor/Carcinoma Spindle Cell Neoplasms of Gastrointestinal Tract, Including Gastrointestinal Stromal Tumors CEREBROSPINAL FLUID Normal Cerebrospinal Fluid and Contamination by Normal Elements Infectious Meningitis Aseptic and Mollaret Meningitis Subarachnoid Hemorrhage Neurodegenerative Diseases Primary Brain Tumors Leukemia and Lymphoma Metastasis in Cerebrospinal Fluid PLEURAL, PERITONEAL, PERICARDIAL, AND PELVIC FLUID AND WASHINGS Normal Cellular Components, Reactive Mesothelial Proliferations, and Reporting Terminology Infectious Conditions Autoimmune Diseases Mesothelioma in Effusions and Fine Needle Cytology Malignant Effusion, Carcinomas Metastatic Sarcomas in Effusions and Washings Lymphoid Effusions and Secondary Involvement by Hematopoietic Neoplasms Primary Effusion Lymphoma Endometriosis and Endosalpingiosis Ovarian Neoplasms Immunocytochemistry, Histochemistry, and Other Ancillary Techniques URINARY CYTOLOGY Normal Urinary Cytology, Specimen Types, and Reporting Terminology Ileal Conduit Specimens Noninfectious Benign Conditions Infectious Benign Conditions Reactive Urothelial Changes Low-Grade Urothelial Lesions Atypical Urothelial Cells High-Grade Urothelial Cancer Squamous Cell Carcinoma of Urinary Bladder Adenocarcinoma of Urinary Bladder Other Malignancies in Urinary Cytology Renal Pelvic Cytology Ancillary Testing, UroVysion, and Others SECTION 3: FINE-NEEDLE ASPIRATION, SUPERFICIAL OVERVIEW Superficial Aspiration Technique THYROID GLAND Ultrasound-Guided Thyroid Fine-Needle Aspiration Thyroid Fine-Needle Aspiration Reporting Terminology and Specimen Adequacy Thyroid Follicular Nodular Disease Chronic Lymphocytic/Hashimoto Thyroiditis Granulomatous Thyroiditis Graves Disease/Diffuse Toxic Goiter Pigmented Thyroid Lesions and Crystals Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance Follicular Neoplasm/Suspicious for a Follicular Neoplasm Oncocytic Follicular Neoplasm in Thyroid Fine-Needle Aspiration Papillary Thyroid Carcinoma, Classic Subtype Papillary Thyroid Carcinoma Subtypes Medullary Thyroid Carcinoma Poorly Differentiated Thyroid Carcinoma Anaplastic Thyroid Carcinoma Thyroid Lymphoma Metastatic Carcinoma to Thyroid Other Thyroid and Perithyroidal Lesions Encountered in Fine-Needle Aspiration PARATHYROID GLAND Parathyroid Cyst, Adenoma, and Carcinoma LYMPH NODES Overview Lymph Node Aspiration: Indications, Techniques, and Reporting FNA Sample Prep and Triage in Evaluating Suspected Lymphoma Benign, Infectious, and Reactive Hyperplasia Inflammatory and Reactive Lymphoid Hyperplasia Granulomatous Lymphadenitis, Infectious and Sarcoid Rosai-Dorfman Disease Metastatic Malignancies HPV-Mediated Carcinomas in Neck Lymph Nodes Metastatic Melanoma Other Metastatic Malignancies Encountered in Lymph Node Fine-Needle Aspiration Nodal B-Cell Lymphoma Small Lymphocytic Lymphoma Lymphoplasmacytic Lymphoma Mantle Cell Lymphoma Nodal Marginal Zone Lymphoma Follicular Lymphoma Burkitt Lymphoma Large B-Cell Lymphoma Extranodal B-Cell Lymphoma Plasmacytoma Mediastinal Large B-Cell Lymphoma Plasmablastic Lymphoma T-Cell Lymphoma Peripheral T-Cell Lymphoma Mycosis Fungoides Angioimmunoblastic Lymphoma ALK(+) Anaplastic Large Cell Lymphoma T-Cell Lymphoblastic Lymphoma Hodgkin Lymphoma Nodular Lymphocyte-Predominant Hodgkin Lymphoma Classic Hodgkin Lymphoma EYE Approach to Ophthalmic Cytology Infections in Ophthalmic Cytopathology Neoplasms in Ophthalmic Cytopathology SALIVARY GLAND Overview Approach to Interpretation of Salivary Gland Aspiration Biopsies and Reporting Terminology (Milan System) Benign Lesions Normal Salivary Gland and Sialadenitis on Aspiration Cysts Pleomorphic Adenoma Warthin Tumor Myoepithelioma Salivary Gland Oncocytoma Malignant Neoplasms Adenoid Cystic Carcinoma Acinic Cell Carcinoma Mucoepidermoid Carcinoma Basaloid Neoplasms, Benign and Malignant Carcinoma Ex Pleomorphic Adenoma Adenocarcinoma, NOS Polymorphous Adenocarcinoma Salivary Duct Carcinoma Salivary Gland Secretory Carcinoma Myoepithelial Carcinoma Cribriform Adenocarcinoma Metastatic Carcinoma Primary and Metastatic Nonepithelial Tumors BREAST Overview Role of Fine-Needle Aspiration of Breast, Techniques and Triple Test Benign Breast Lesions Inflammatory and Granulomatous Conditions Fat Necrosis Nonproliferative and Proliferative Changes in Breast Radial Scar/Complex Sclerosing Lesion Gynecomastia Mucocele-Like Lesion Benign Neoplasms Fibroadenoma Granular Cell Tumor of Breast Papillary Neoplasms Myofibroblastoma, Mammary Malignant Neoplasms Ductal Carcinoma and Variants of Invasive Mammary Carcinoma Lobular Carcinoma Phyllodes Tumor Angiosarcoma and Other Sarcomas Lymphomas and Metastatic Tumors Nipple Discharge Cytology Specimens for Risk Assessment of Breast Cancer SKIN AND SUBCUTANEOUS CYTOLOGY Cutaneous and Adnexal Cytology Fat Pad Aspiration for Amyloid SECTION 4: FINE-NEEDLE ASPIRATION, DEEP ORGANS AND TISSUES OVERVIEW Techniques and Modalities of Deep Aspiration Biopsies Techniques and Modalities of Bronchoscopic Aspiration and Small Biopsies Techniques and Modalities of Gastrointestinal Endoscopic Aspiration and Small Biopsies RESPIRATORY TRACT, INCLUDING LUNG FNAS Specimen Types in Respiratory Cytology and Adequacy Criteria Benign and Reactive Changes Fungal Yeasts and Hyphal Organisms Pneumocystis Pneumonia Parasitic Organisms Viral Infections (Cytomegalovirus, Herpesvirus, and Others) Mycobacteria and Other Bacterial Infections Sarcoidosis and Other Immune-Related Conditions Pulmonary Alveolar Proteinosis and Mimics Miscellaneous Findings, Including Contaminants Adenocarcinoma of Lung Squamous Cell Carcinoma of Lung Small Cell Carcinoma of Lung Large Cell Neuroendocrine Carcinoma of Lung Carcinoid and Atypical Carcinoid of Lung Rare Benign and Low Malignant Potential Tumors Rare Malignant Tumors NUT Carcinoma SMARCA4 -Deficient Undifferentiated Tumor Pulmonary Lymphoma Pulmonary Metastasis MEDIASTINUM Overview Anatomic Compartments and Constituent Tumors Nonneoplastic Lesions Mediastinal Cysts and Inflammatory Lesions Neoplasms Thy.