Section 1: Introduction and basic concepts in cell biology and biochemistry.- Introduction to Biochemistry, Molecular and Cell Biology, and Their Pharmaceutical Applications.- Introduction to Cells in Health and Disease.- Membranes and Membrane Transport in Cell Biology and Drug Action.- Section 2: Basic Protein Structure and Function.- Amino Acids and Protein Structure.- Enzymes, Their Catalytic Properties, and Enzymes as Drug Targets.- Section 3: The Flow of Genetic Information.
- DNA and DNA Replication in Normal Cells and Disease.- RNA and Transcription, Abnormalities in Gene Expression in Disease.- Translation, Protein Synthesis, Protein Folding, and Turnover, Pharmacological Interventions That Modulate Protein Turnover.- Section 4: Carbohydrates, lipids, their structure, and metabolism.- Carbohydrates and Lipids.- Carbohydrate Metabolism and Their Role as an Energy Source.- Lipid Metabolism, Lipids in Diet, Health and Disease.- Homeostasis and Regulation of Metabolism in Human Health.
- Disorders of Carbohydrate and Lipid Metabolism, and Pharmacological Treatments.- Section 5: Metabolism beyond carbohydrates and lipids.- Amino Acid Metabolism, Related Disorders, and Treatments.- Nucleotide Metabolism and Therapeutic Targets.- One-Carbon Metabolism.- The Role of Vitamins in Human Health and the Effects of Vitamin Deficiencies.- Section 6: Advanced topics.- Signal Transduction and Drugs That Target Signaling Pathways.
- Cancer Cells, Oncogenes, and Therapeutic Interventions.- Regulation of the Cell Cycle and Abnormalities in Disease.- Tumor Suppressor Genes and Cancer.- Cell Death and Recycling.- DNA Damage and Repair: Implications for Health and Disease.- Introduction to the Immune System and Virology for Pharmaceutical Sciences.- Section 7: Emerging technologies.- CRISPR and Gene Therapy in Modern Medicine.
- Stem Cells and Cellular Therapy.- Introduction to Omics Technologies for Research, Diagnosis, and Drug Discovery.- Drug Delivery and Nanotechnology.- Appendix A: Basic Biochemical Concepts.- Appendix B: Shuttles and Cycles.- Appendix C: Nonstandard Transamination Reactions.