List of Contributors xvi Preface to the Fourteenth Edition xxii Preface to the First Edition xxiii Acknowledgement xxiv 1 Global Epidemiology and Burden of Liver Disease 1 Markos Kalligeros and Zobair M. Younossi 2 Anatomy and Function 14 Pooja Khonde and Lei Zhao 3 Liver Function in Health and Disease: Clinical Application of Liver Tests 33 George Mells and Neliswa Gogela 4 Jaundice and Cholestasis 53 Richard J. Thompson and Jeremy S. Nayagam 5 Biopsy of the Liver 70 David Patch and Tu Vinh Luong 6 Haemostasis in Liver Disease 83 Jessica P.E. Davis, Stephen H. Caldwell, and Nicolas M. Intagliata 7 Acute Liver Failure 99 Shannan R.
Tujios, Constantine Karvellas, and William M. Lee 8 Hepatic Fibrogenesis 123 Meena B. Bansal and Scott L. Friedman 9 Non-invasive Assessment of Fibrosis and Cirrhosis 135 Emmanuel A. Tsochatzis and Leon A. Adams 10 Hepatic Cirrhosis and Portal Hypertension 156 Yu Jun Wong and Juan G. Abraldes 11 Ascites 172 Anahita Rabiee and Guadalupe Garcia-Tsao 13 Varices and Variceal Haemorrhage 256 Dhiraj Tripathi and Dominique Thabut 14 Palliative Care and Symptom-Based Management in Decompensated Cirrhosis 287 Alan Noll and Shari Rogal 15 Acute-on-Chronic Liver Failure and Critical Care Management of Cirrhosis 311 Rajiv Jalan and Constantine J. Karvellas 16 Vascular Disorders of the Liver and Extrahepatic Portal Hypertension 332 Virginia Hernández-Gea 17 Gallstones and Benign Biliary Disease 362 Brian R.
Davidson and George J. Webster 18 Malignant Biliary Diseases 402 Marina I. Crespo Cruz and John Bridgewater 19 Fibropolycystic Liver Diseases and Congenital Biliary Abnormalities 416 Mario Strazzabosco and Kathleen M. Loomes 20 Primary Biliary Cholangitis 437 Adriaan J. van der Meer and Palak J. Trivedi 21 Primary and Secondary Sclerosing Cholangitis 468 Natassia Tan and Gideon M. Hirschfield 22 Autoimmune Hepatitis and Overlap Syndromes 489 Ilkay Ergenc and Michael A. Heneghan 23 Enterically Transmitted Viral Hepatitis: Hepatitis A and Hepatitis E 519 Alexandra N.
Willauer and Kenneth E. Sherman 24 Hepatitis B 536 Wen-Juei 25 Hepatitis D 578 Patrizia Farci and Grazia Anna Niro 26 Hepatitis C 600 Geoffrey Dusheiko and Mark W. Sonderup 27 Drug-Induced Liver Injury 642 Alisa Likhitsup and Robert J. Fontana 28 Alcohol and the Liver 672 Ewan Forrest 29 Iron Overload States 694 Heinz Zoller and Paul C. Adams 30 Wilson Disease 716 Eve A. Roberts and Karl Heinz Weiss 31 Metabolic Dysfunction-Associated Steatotic Liver Disease 733 Fasiha Kanwal and Vincent Wai-Sun 32 Nutrition and Chronic Liver Disease 768 Manuela Merli and Jaya Benjamin 33 Pregnancy and Liver Conditions 782 Monika Sarkar and Catherine Williamson 34 The Liver in the Neonate, Infancy, and Childhood 801 Rebecca Jeyaraj and Deirdre A. Kelly 36 The Liver in Infections 875 Alex Kew and Sanjay Bhagani 37 Imaging of the Liver and Diagnostic Approach of Space-Occupying Lesions 911 Neil H. Davies and Dominic Yu 38 Benign Liver Tumours 923 Ashley E.
Stueck and Ian R. Wanless 39 Primary Malignant Neoplasms of the Liver 938 Daniel Q. Huang and Amit G. Singal 40 Hepatic Transplantation: Pretransplant Management 965 Lindsay Y. King and Carl L. Berg 41 Hepatic Transplantation: Posttransplant Management 997 Divya Ayyala-Somayajula and Norah A. Terrault Index 1039.