Section I: Introduction to Lung Cancer and Epigenetics 1. Lung Cancer: Epidemiology, Pathophysiology, and Current Therapies 2. The Role of Epigenetic Alterations in Lung Cancer Progression 3. Epigenetic Therapy: Overview and Emerging Frontiers Section II: Phytochemicals as Epigenetic Modulators 4. Introduction to Phytochemicals with Epigenetic Activity 5. DNA Methylation Modulation by Phytochemicals 6. Histone Modification Regulation by Plant-based Compounds 7. Impact of Phytochemicals on Non-coding RNAs in Lung Cancer Section III: Phytochemicals in Lung Cancer Therapy - Mechanisms and Evidence 8.

Polyphenols as Epigenetic Modulators: Curcumin, Resveratrol, and Quercetin 9. Flavonoids and Epigenetic Therapy in Lung Cancer 10. Terpenoids and Their Role in Lung Cancer Epigenetic Modulation 11. Alkaloids and Lung Cancer Epigenetics: Mechanistic Insights and Case Studies Section IV: Clinical Implications and Future Directions 12. Preclinical and Clinical Trials of Phytochemicals in Lung Cancer Epigenetics: * 13. Insights into clinical trials and real-world applications of phytochemicals 14. Challenges in Phytochemical-based Epigenetic Therapy 15. Formulation and Delivery Systems for Phytochemical-based Epigenetic Drugs 16.

Combination Therapies: Phytochemicals with Conventional Lung Cancer Therapies 17. Conclusion and Future Perspectives in Epigenetic Phytotherapy for Lung Cancer 18. Cancer immunotherapy, including CAR-T cell therapy and immune checkpoint inhibitors.