Part I: Molecular and Cellular Mechanisms Underlying Cancer Resistance (Chapters 1-5) 1. Molecular Pathways in Cancer Resistance: A Comprehensive Overview 2. Role of Tumor Microenvironment in Therapy Resistance 3. Epigenetic Modifications and Drug Resistance in Cancer 4. Cancer Stem Cells as Drivers of Resistance to Conventional Therapies 5. Mechanisms of Immune Escape and Resistance to Immunotherapy in Cancer Treatment Part II: Emerging Therapeutic Approaches to Overcome Resistance (Chapters 6-13) 6. Targeting Epigenetic Regulators: Promising Avenues 7. CRISPR and Gene Editing in Combating Drug Resistance 8.

Synthetic Lethality and PARP Inhibitors in Resistant Tumors 9. Role of Nanomedicine in Delivering Targeted Therapies 10. Overcoming Resistance to Immunotherapy with Checkpoint Blockade 11. Exploiting Tumor Metabolism to Reverse Resistance 12. The Role of MicroRNAs and Non-coding RNAs in Therapeutic Resistance 13. Overcoming Cancer Resistance: The Role of Emerging CAR-T Cell Approaches Part III: Clinical Applications and Future Perspectives (Chapters 14-18) 14. Biomarker Development for Predicting Therapy Resistance 15. Precision Medicine in the Context of Cancer Resistance 16.

Combination Therapies to Enhance Treatment Efficacy in Resistant Cancers 17. AI-Driven Approaches to Overcoming Cancer Resistance 18. Future Directions in Overcoming Cancer Resistance: Challenges and Opportunities.