Dr. Fearon's primary area of research interest is in coronary physiology. He has been the principal investigator of numerous multicenter clinical trials, including the FAME trials, which have resulted in multiple publications in the New England Journal of Medicine and led to worldwide adoption of the use of coronary physiology to guide revascularization decisions in the cardiac catheterization laboratory. He also derived and validated the index of microcirculatory resistance, which is now used commonly to assess coronary microvascular function. He has over 250 publications, speaks regularly at major international conferences, and serves on the editorial board of the Journal of the American College of Cardiology, Circulation, JACC Cardiovascular Interventions, and Circulation: Cardiovascular Interventions, among other journals. His research laboratory has had near continuous NIH funding and he is currently the principal investigator on an NIH grant evaluating cardiac allograft vasculopathy. He has received multiple teaching awards from Stanford University and has mentored numerous clinician-scientists.