Vasan is a noninvasive cardiologist with specialization in cardiovascular epidemiology, and a senior investigator at the Framingham Heart Study. He is the co-director of the echocardiography and vascular testing laboratory at the Framingham Heart Study and he directs its fellowship training program. His epidemiological research has focused on 4 inter-related areas: a. the epidemiology of congestive heart failure, including identifying risk factors for the disease, characterizing the subgroups with diastolic heart failure, asymptomatic LV systolic and diastolic dysfunction, and evaluating the role of LV remodeling; b. population-based vascular testing and echocardiography, including identifying biological, environmental, and genetic determinants (correlates) of cardiac structure and function; normative standards; detailed assessment of biomarkers of the process of LV remodeling; c. epidemiology of high blood pressure, including characterizing the lifetime risk, rates of progression and risks associated with various degrees of elevation; and, d. exercise physiology, and exercise test responses in asymptomatic individuals and prognostic information; relations to endothelial function.