Part 1. Protein aggregation in different proteinopathies 1. Amyloid-pore hypothesis: prefibrillar oligomers interaction with membranes; a generic cause of neurodegeneration? 2. In vivo molecular brain imaging of metabolic (dys)function and protein accumulation in neurodegenerative disease 3. Amyotrophic lateral sclerosis: Relevance of protein aggregation of TDP-43 and mechanisms of toxicity 4. Cystatin C amyloid angiopathy (CAA) and AD: Interaction of cystatins oligomers with A-beta 5. Protein aggregation and disturbed proteostasis in mental illness, stress on shizophrenia 6. Protein aggregation in progressive myoclonus epilepsies, in particular EPM1 7.

Model amyloid proteins: What are the lessons to understand proteinopathies Part 2. Common signaling pathways and biomarkers of disease 8. The integrated stress response: from mechanism to disease 9. Comparison of AD and schizophrenia: From signaling to biomarkers 10. Oxidative stress and mitochondrial decline in common to several proteinopathies 11. Irisin reduces amyloid-b by inducing the release of neprilysin from astrocytes following down regulation of ERK-STAT3 signaling 12. Dysregulated molecular pathways in amyotrophic lateral sclerosis-frontotemporal dementia spectrum disorder Part 3. Small molecules as modulators of the key processes in proteinopathies 13.

Trem2 signaling modulators to treat neurodegenerative disease 14. Small molecules modulators of protein aggregation and toxicity: antioxidants and polyphenol compounds 15. Therapeutic Strategies to Mitigate the Toxicity of α-Synuclein Oligomers in Parkinson's Disease 16. Repurposed drugs that modulate proteinopathies 17. Future of metal chelators in AD therapy 18. Novel dual-acting hybrids targeting type-2 cannabinoid receptors and cholinesterase activity show neuroprotective effects in vitro and amelioration of cognitive impairment in vivo 19. Role of autophagy in neurodegeneration and aging; small molecule modulators 20. NEW treatments on the horizon for Alzheimer's and other neurodegenerative diseases Part 4.

Modern biophysical methods, molecular dynamics and machine learning 21. Intrinsically unfolded proteins and the role of protein condensation 22. A-beta: Structure and interaction with membranes as revealed by NMR 23. Oligomers formation by amyloid beta as studied by coarse-grain MD 24. Machine learning in prediction of protein aggregation and/or condensation states.