Pacap : From Discovery to Function

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ISBN No.:	9780443290541
Year:	202603
Format:	Trade Paper
Price:	$ 255.50
Dispatch delay:	Dispatched between 7 to 15 days
Status:	Available (Forthcoming)

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Synopsis
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I. Introduction II. Pituitary adenylate cyclase-activating polypeptide 1. Discovery and biochemical properties of PACAP (Secondary structure of PACAP, Structure of the PACAP precursor and post-translational processing) 2. Cloning and phylogenetic evolution of the PACAP gene 3. Development of PACAP peptidic analogs for structure-activity characterization 4. Development of PACAP small molecule agonists / antagonists for therapeutic applications III. PACAP receptors 5.

Pharmacological, Biochemical and Signaling characterization of PACAP receptors 6. Cloning and phylogenetic evolution of PACAP receptors IV. Expression of PACAP and its receptors 7. Distribution of PACAP and its receptors in the central nervous system (at adulthood and during development) 8. Distribution of PACAP and its receptors in peripheral organs (at adulthood and during development) 9. Presence of PACAP in biological fluids 10. Expression and functional implication of PACAP and its receptors in tumor cells V. Biological actions of PACAP in normal and pathological conditions A.

Actions of the CNS 11. Actions on the hypothalamus 12. Actions of PACAP on the pineal gland and circadian rhythms 13. Actions on glial cells 14. Effects of PACAP on the pituitary gland 15. PACAP transport across the BBB and therapeutic implication 16. Neurotrophic actions during development and protective effects in acute brain injuries (stroke and spinal cord) 17. Protective effect of PACAP in neurodegenerative diseases 18.

PACAP in migraine 19. Action of PACAP in the central regulation of energy homeostasis, including food intake 20. Behavioral actions of PACAP 21. PACAP and stress 22. PACAP and pain 23. PACAP and psychiatric disorders B. Actions on peripheral organs 24. Effects of PACAP on the eye 25.

Effects of PACAP on the thyroid gland 26. Effects of PACAP on the gonads 27. Effects of PACAP on the adrenal gland 28. Effects of PACAP on the gastrointestinal tract 29. Effects of PACAP on the liver 30. Effects of PACAP on the pancreas 31. Effects of PACAP on the respiratory system 32. Effects of PACAP on the cardiovascular system 33.

Effects of PACAP on immune cells 34. Effects of PACAP on bones.

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