This book includes select proceedings papers presented at the 4th Structural Integrity Conference and Exhibition (SICE-2022), organized at the Indian Institute of Technology (IIT), Hyderabad. The papers by eminent scientists and academicians broadly working in aerospace, civil, and mechanical and materials engineering within the areas of structural integrity, life prediction, and condition monitoring are classified under the domains of aerospace, fracture mechanics, fatigue, civil structures, experimental techniques, computation mechanics, molecular dynamics and nanostructures, smart materials, energy impact, dynamics, mechanisms, structural optimization, composites, AI/ML applications, additive and advanced manufacturing, bio-engineering, structural health monitoring, nondestructive testing, and damage and failure analysis. The contents of this book serves as a valuable resource for researchers, students, and practicing engineers alike.