PSAs shape nuclear safety decisions by consolidating methodological reliability and site-level risk insights. The objective of this Safety Guide is to provide recommendations for meeting the requirements of GSR Part 4 (Rev. 1) in the development and application of Level 1 Probabilistic Safety Assessments (PSAs) for nuclear power plants (NPPs). The recommendations provided in this publication promote technical consistency among Level 1 PSA studies in order to provide reliable support for applications of PSAs and risk informed decision making, particularly to support the design of NPPs and decision making during plant commissioning and operation. The revised Safety Guide's scope encompasses the main methodological aspects of PSA and in particular has been updated to reflect developments in specific areas, such as passive systems reliability, computer based systems reliability, combinations of hazards, human reliability analysis and to expand the scope of PSA to include site level risk considerations such as multi-unit and spent fuel pool PSA.