This book extends the discussion begun in previous two volumes, expanding the focus to include the economic, educational, medical, and human factors that shape the future of space exploration. Reflecting the broad and interdisciplinary scope of the XLVI and XLVII Academic Space Conferences, this book highlights innovative research on mission design, innovation management, and astronaut-centered engineering. In particular, this focuses on trajectory planning, lunar logistics, economic models for the space sector, STEM education for space careers, and biomedical studies on life support and long-duration missions. Reflecting on technical and socio-economic aspects of space exploration, this book is invaluable for a broad audience of researchers, educators, and industry leaders seeking insight into the evolving intersection of technology, policy, and human systems in space science.