Sensors, Circuits, and Systems for Scientific Instruments: Fundamentals and Front-Ends presents a unified treatment of modern measurement systems by integrating relevant knowledge in sensors, circuits, and signal processing, it also presents case studies of real-life measurement systems to illustrate how theoretical analysis and high-level designs are translated into working scientific instruments. The book is meant for upper-level undergraduate and beginning graduate students in electrical and computer engineering, applied physics, and biomedical engineering. It is designed to fill a gap between books focused on specific components of measurement systems (such as semiconductor devices, analog circuits, or digital signal processing) and books that provide a high-level survey or handbook-type overview of a wide range of sensors and measurement systems. Here are some key features of the book: Develops a unified treatment of modern scientific instruments by combining knowledge of high-performance sensors, semiconductor devices, circuits, signal processing, and embedded computing. Focuses on fundamental concepts in precision sensing and interface circuitry (such as accuracy, precision, linearity, and noise) and their impact on system-level performance instead of specific types of sensors. Presents multiple case studies and examples to demonstrate how theoretical concepts are translated into real-life measurement systems.