This volume details protocols that highlight the versatility of LCM across different biological contexts and analytical workflows. Chapters cover protocols on isolating cells from blood smears, live cell samples, and FFPE or frozen tissues. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips for troubleshooting and avoiding known pitfalls. Authoritative and practical, Laser Capture Microdissection: Methods and Protocols aims to support both new and experienced researchers in effectively applying LCM to their own biological questions, across a wide variety of systems and technical platforms.