This book is an introduction to probability, statistics, data analysis, and hypothesis testing in physics. It is designed to be taught at different levels, from basic to advanced, and to be enjoyed by anyone doing research in the physical sciences or related subjects. It aims to be a companion in a journey leading the reader to appreciate and enjoy the major role of these subjects in all aspects of the physical sciences. With specific examples, the book encourages readers to meditate on the distinctive meaning of probability in classical and quantum physics. The author draws on his teaching experience in statistical physics and data analysis, as well as his research work in fields like complex systems and soft matter, to provide a comprehensive introduction to statistical methods.