This highly informative Handbook brings together international scholars to advance the evolving field of digital social science. It articulates a renewed vision for the field by exploring its historical foundations, emergent formations and future possibilities. Expert contributors argue that the future of digital social science lies in the synergistic integration of social science methodologies and technical expertise, oriented toward ethical outcomes. The Handbook introduces the theoretical concept of the Digital Social Science Pentagon, a new typology that acts as the structural anchor by outlining five key nodes of study: transitions, branches, interdisciplinarity, applications, and ethical futures. Key topics covered include issues of governance, policy experiences, child development, and digital inequality and oppression. The Handbook ultimately underscores the urgent need for collaborative, cross-disciplinary knowledge to address complex societal challenges and shape responsible and ethical digital futures. The Handbook of Digital Social Science is an essential read for scholars and students of various intersections of digital studies including ethics, engineering, business, entrepreneurship, criminology, public policy, public health, law, and sociology. It also provides valuable insights for digital social scientists, theorists, and methodologists interested in collaborative knowledge, interdisciplinary dialogue, and technical expertise.