The descriptive and comprehensive guidelines in this collection reflect evidence-based practices for perioperative teams. Each AORN of the 36 guidelines includes recommendations intended to be achievable and to represent what is believed to be an optimal level of perioperative patient care and workplace safety. Each guideline contains recommendations that are broad statements to be used to guide the development of policies, procedures, and criteria for measuring individual competency in a variety of practice settings where operative and other invasive procedures are performed. The guidelines are informed by a comprehensive systematic review of research and non-research evidence, appraisal of this evidence for strength and quality, and assessment of the benefits and harms of alternative care options. When adhering to the AORN Guidelines for Perioperative Practice, perioperative clinicians can be confident that they are following trustworthy guidelines developed in accordance with the principles set forth by the National Academy of Medicine.